Insulin - Dependent Diabetes Mellitus Review

*Department of Microbiology and Immunology et al., 1995) and adhesion molecules (very late antigen School of Medicine 4) (Yang et al., 1993). University of North Carolina at Chapel Hill Studies of rodent models and preliminary studies in Chapel Hill, North Carolina 27599 man have shown that the completion of b cell destruc†Department of Microbiology and Immunology tion can beconsiderably delayed or prevented by parenDepartment of Medicine teral administration of b cell autoantigens—including School of Medicine insulin, glutamic acid decarboxylase (GAD), and heat Stanford University shock protein 60 (HSP60). A number of studies have Stanford, California 94305-5402 also shown that manipulation of cytokine networks by